Possible Interaction: Copper and Resveratrol

“The studies analyzed show that resveratrol is able to modulate the oxidative stress generated by different heavy metal compounds such as As, Cd, Cu , Cr and Fe.”

“However, Fukuhara and Miyata have shown a non-proteic reaction of Rsv , which can act as a prooxidant agent in the presence of copper (Cu), causing cellular oxidative stress accompanied of DNA damage.”

“Thus, while CA and RES might aggravate the oxidative/nitrative damage of Cu , CUR should be considered as a putative protective agent.”

“Nevertheless, depending on the concentration of the phytoalexin and the cell type, it has also been shown that resveratrol can exhibit pro-oxidant properties, leading to oxidative breakage of cellular DNA in the presence of transition metal ions such as copper.”

“Recently, however, resveratrol was reported to promote DNA fragmentation in the presence of copper ions (K. Fukuhara and N. Miyata, 1998, Bioorg.”

“ Resveratrol (50 microM) reduced TBARS and REM of LDL during Cu(2+)-induced oxidation by 70.5% and 42.3%, respectively (p < 0.01), and prolonged the lag phase associated with the oxidative modification of LDL by copper ion or azo compound.”

“Similarly, copper significantly decreased in diabetic groups treated with RSV.”

“It has recently been shown that resveratrol induces strand breakage in DNA in the presence of copper ions.”

“As compared to flavonoids and trolox, transresveratrol showed a much higher ability to prolong the lag time in copper , but not in AAPH-catalyzed oxidation.”

“At 1 microM, transresveratrol prolonged the lag time 3.4- and 1.4-fold in the presence of copper and AAPH, respectively.”

“Similar αS aggregation inhibitory effects were observed with resveratrol only in the presence of the copper ion.”