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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Since Platinum and Cu share uptake receptors, the synergism by drugs containing these metals should not be under-estimated.”
Cancer Pro-oxidant Therapy Through Copper Redox Cycling: Repurposing Disulfiram and Tetrathiomolybdate.“These results … concentration of copper causes a significant increase in … CDDP and binding of platinum to DNA independently of CTR1 expression in KB cells and CDDP-resistant sublines thereof and that the … resistance is associated with a greatly reduced level of ATP7A and a marginally lower expression of CTR1.”
“Interestingly, the platinum binding weakens the CuI coordination, but does not expel the copper ion from MBDs.”
Differential Reactivity of Metal Binding Domains of Copper ATPases towards Cisplatin and Colocalization of Copper and Platinum.
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