Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Copper and Penicillamine

supplement:

Copper

Research Papers that Mention the Interaction

The electrochemical response of copper is changed considerably in the presence of negligible amount of PA.
Bioelectrochemistry  •  2014  |  View Paper
Cell cytotoxicity resulting from the incubation of D-penicillamine with copper was compared to that of D-penicillamine, copper and hydrogen peroxide.
Journal of inorganic biochemistry  •  2007  |  View Paper
D-pen in the presence of copper also resulted in a reduction in intracellular reduced thiol levels.
Free radical biology & medicine  •  2007  |  View Paper
The results indicate that D-Penicillamine in synergism with copper or ceruloplasmin in vitro inhibits the proliferation of T-lymphocytes and the activity of helper T-cells in supporting the generation of antibody-forming cells.
Zeitschrift fur Rheumatologie  •  1988  |  View Paper
Additional studies confirmed that D-penicillamine inhibited PHA-induced mitogenesis of lymphocytes in the presence of copper , and that catalase protected the cells from this action.
Furthermore, when polymorphonuclear leukocytes were incubated with D-penicillamine plus copper , hexose monophosphate shunt activity increased up to threefold with abrogation of this stimulation by catalase.
Recent studies have suggested that the inhibition of lymphocyte mitogenesis by D-penicillamine in the presence of copper could be mediated by the formation and action of hydrogen peroxide.
The addition of copper to D-penicillamine in physiologic buffer catalyzed D-penicillamine oxidation in a dose-dependent fashion.
Journal of immunology  •  1985  |  View Paper
The formation of stable complexes between penicillamine and copper or nickel (whether they are of the binary or mixed ligand type) may be important in the therapeutic action of this drug.
Biochemical pharmacology  •  1985  |  View Paper
DP added to copper produced H2O2.
Arthritis and rheumatism  •  1985  |  View Paper
Data obtained indicate that D-penicillamine alters the metabolism of both copper and zinc.
Archives of disease in childhood  •  1985  |  View Paper
These results indicate that the mechanism whereby D-penicillamine in the presence of copper or ceruloplasmin inhibits T lymphocyte responsiveness involves the generation of hydrogen peroxide and that other neighboring cells likely to be found w
The Journal of clinical investigation  •  1984  |  View Paper
It is hypothesized that decreased copper availability secondary to penicillamine therapy may result in defective elastin within the lamina of Bruch with resultant defects in the overlying retinal pigment epithelium.
Annals of ophthalmology  •  1978  |  View Paper
Show More