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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Copper
drug:
Penicillamine
Research Papers that Mention the Interaction
“TM, EDTA, PEN , BAL and DDC adminstration increased Cu excretion via bile and urine by 254, 11, 266, 46 and 16%, respectively in Group A sheep, and by 354, 13, 196, 20 and (-) 31% in Group B sheep.”
Effect of chelating agents on the excretion of copper, zinc and iron in the bile and urine of sheep.“ D-penicillamine was shown to increase rat hepatic metallothionein levels; however, the effect was dependent on an interaction with copper.”
“This interaction of penicillamine and copper also provoked changes in the distribution of zinc and in particular an increase in the heat-stable cytosol zinc fraction.”
The interactions of penicillamine with copper in vivo and the effect on hepatic metallothionein levels and copper/zinc distribution: the implications for Wilson's disease and arthritis therapy.“ Penicillamine , another agent associated with neutropenia and, like captopril, having a reactive thiol group, also inhibited colony formation in the presence of copper.”
“In 1956, Walsheg reported that the oral administration of penicillamine increases the urinary excretion of copper in patients with Wilson's disease.”
“The metal-binding agent penicillamine increases the urinary excretion of copper and a number of other heavy metals.”
“The key strategy of treatment is to reduce the amount of copper in the liver and other tissues by administering both copper-chelating agents, such as D-penicillamine or Trientine, and/or zinc acetate.”
“Fluorescence enhancement efficiency of Cu NCs induced by d-PA was linear, with the d-PA concentration varying from 0.6-30 μg ml-1 (R2 = 0.9952) and with a detection limit of 0.54 μg ml-1 .”
“The electrochemical response of copper is changed considerably in the presence of negligible amount of PA.”
“Cell cytotoxicity resulting from the incubation of D-penicillamine with copper was compared to that of D-penicillamine, copper and hydrogen peroxide.”
“ D-Penicillamine (D-pen), a copper-chelating agent, at low concentrations in the presence of copper generates concentration-dependent cytotoxic hydrogen peroxide (H(2)O(2)).”
“ D-pen in the presence of copper also resulted in a reduction in intracellular reduced thiol levels.”
“Copper chelators, diethyldithiocarbamate and penicillamine , also inhibited the Cu ,Zn-SOD/H(2)O(2) system-induced alpha-synuclein aggregation.”
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