Possible Interaction: Copper and Nitric Oxide

“Results: In vitro, copper decreased markedly the survival of neuronal cells and enhanced the production of nitric oxide (NO).”

“Conversely, nitric oxide is a potent inhibitor of LDL oxidation when initiated by copper ions or by azo-initiators.”

“In the presence of copper , the copA mutant exhibited increased sensitivity to killing by nitrite or nitric oxide.”

“In addition, Cu exposure markedly changed the levels of glutathione, catalase, and total antioxidant capacity, and upregulated the contents of protein carbonyl, nitric oxide , and malondialdehyde.”

“Arteries from Cu supplemented rats exhibited an enhanced vasodilation to gasotransmitters: nitric oxide (NO) and carbon monoxide (CO).”

“ Cu treatment increased malondialdehyde, nitric oxide level, and myeloperoxidase activity and decreased superoxide dismutase and catalase activities in rat brain.”

“Approximately 25% of neurones contain nNOS and the NO produced can modulate the firing rate of the main principal cells: medium stellates ( choppers ), large stellates (onset responses) and bushy cells (primary‐like responses).”

“The persistent activation of microglia with the subsequent release of NO vis-á-vis … transition metals such as copper (Cu) in neurodegenerative diseases, prompted the hypothesis that copper … NO signaling by changing the redox environment of the cell and … the fate of NO, microglia would adopt a different phenotype.”

“A concomitant increase in the intracellular NO level was observed with increasing concentrations of Cu applied.”

“The enzymatic generation of nitric oxide (NO) in vivo has been reported to be modulated by ions, such as copper and iron.”