Possible Interaction: Copper and Nicotine

“A significant reduction in the metal contents of copper and zinc in senile plaques and neuropil is observed after nicotine treatment.”

“ Nicotine treatment decreases the intracellular copper concentration and attenuates Aβ‐mediated neurotoxicity facilitated by the addition of copper , and these effects are independent of the activation of nicotinic acetylcholine‐receptor.”

“The densities of copper and zinc distributions in a subfield of the hippocampus CA1 region are also reduced after nicotine treatment.”

“ Copper supplementation during this period of lung development reduced the adverse effect of maternal nicotine exposure on neonatal lung development.”

“Even though copper reduced the adverse effects of maternal nicotine exposure during this phase of lung development, it did not prevent the induction of microscopic emphysema.”

“ Copper supplementation during gestation and lactation prevented the adverse effects of maternal nicotine exposure during gestation and lactation on the development of the alveolar region of the rat lung.”

“It has been shown that, during the phase of lung development associated with alveolarization, maternal nicotine exposure resulted in a reduction in the copper content and thus conceivably in the activity of lysyl oxidase of the neonatal lung.”

“Be, Cu , Pd, Pt, and Sm definitely increased nicotine yield (over 25%), whereas Bi, Co, Ho, Pb, Ni, Rb, Ag, Tl, Sn, U. V. and Zr definitely decreased nicotine yield.”