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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Copper
drug:
Molecular Oxygen
Research Papers that Mention the Interaction
“Paradoxically, the same redox properties of copper can make it extremely dangerous because it can catalyze production of free radical intermediates from molecular oxygen.”
Binding of fatty acids facilitates oxidation of cysteine-34 and converts copper-albumin complexes from antioxidants to prooxidants.“In the presence of molecular oxygen , the BOD cofactor containing 4 copper ions require an overpotential about 150 mV to be reduced as compared to that in the absence of oxygen.”
Assessing electron transfer reactions and catalysis in multicopper oxidases with operando X-ray absorption spectroscopy“The presence of transition biometal ions, specifically copper and iron, induces ROS formation by catalyzing the reduction of molecular oxygen to superoxide anion (O2˙-), hydrogen peroxide (H2O2) and hydroxyl (HO˙) radical.”
“ Copper in the presence of excess 1,10-phenanthroline, a reducing agent, and molecular oxygen causes cleavage of DNA with a preference for T-3',5'-A-steps, particularly in TAT triplets.”
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