Possible Interaction: Copper and Manganese

“ Manganese and copper acted as inverse key players in N‐glycosylation, showing a positive effect of manganese and a negative effect of copper on glycan maturation in a zinc‐dependent manner.”

“Replacement of copper by manganese leads to a loss of enzyme activity and, after a short delay, to proteinase resistance2.”

“It has also been suggested that manganese retards while copper promotes the development of atherosclerosis.”

“The addition of Cu to the Mn load decreased the area under the curve for plasma Mn by about half, but it was not significantly different in the four subjects.”

“The concentration of Mn in the livers and kidneys was significantly higher after 24 weeks, and by 32 weeks liver copper and zinc levels were lower.”

“There was suggestive evidence of interaction between Mn and Cu.”

“Concentrations across firefighter ensemble, inside vehicle cabins, and within fire …-493 μg/m2), lead (46.7-619 μg/m2), copper (594-3440 μg/m2), zinc (11100-….6-2469 μg/m2) and manganese (73.0-997 μg/m2) were in most instances … compared with concentrations measured in homes and offices.”

“CONCLUSIONS: The clinical and nutritional status as well as intake of nutrients with antioxidant properties ( u, Zn, M n, vitamin C and ω3) appears to modulate the variation of NO in this population.”

“By analysis of the relations between elements, it was observed that total level of Cu correlated with total levels of Mg and Mn , which indicates a synergistic interaction between the essential elements under study.”

“Elevated Mn levels among welders may alter the homeostasis of Cu and Zn.”