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Last Updated: 2 years ago

Possible Interaction: Copper and Levodopa

supplement:

Copper

Research Papers that Mention the Interaction

Herein, we investigate the pro-oxidant DNA damage induced by the interaction of L-DOPA and dopamine (DA) with copper.
Toxicology in vitro : an international journal published in association with BIBRA  •  2017  |  View Paper
These findings demonstrate that L-DOPA exhibits a pro-oxidant activity in the presence of copper ions.
Advances in experimental medicine and biology  •  2015  |  View Paper
With a mean daily dose of 12.65 mg, CU 32-085 together with levodopa plus a decarboxylase inhibitor produced a significant reduction in akinesia, rigor and tremor.
Journal of Neurology  •  2004  |  View Paper
In vitro experiments have shown that in the presence of divalent copper ions, levodopa may induce intense DNA damage.
Phytotherapy research : PTR  •  2007  |  View Paper
Several metabolites including L-3,4-dihydroxyphenylalanine and dopamine have been previously shown to lead to oxidative DNA breakage in the presence of copper ions.
Neuroscience Letters  •  2001  |  View Paper
Moreover, chemicals that bind to copper and inhibit copper-containing enzymes such as laccase completely inhibited antigen secretion in response to L-DOPA.
Phytopathology  •  1997  |  View Paper