Possible Interaction: Copper and Iron, Dietary

“Although feeding of formulas with iron concentration of 215 mumol/L (12 mg/L) is a reliable means of preventing iron deficiency, high intakes of iron may adversely affect absorption of copper and zinc.”

“On the other hand, Cu supplementation significantly increased Fe concentration in livers of hens fed the Fe-supplemented diet (P < 0.01).”

“Supplementation of the basal diet with the combination of Zn and Fe , however, significantly decreased hepatic concentration of Cu.”

“The combination of Fe with Zn and Cu , however, increased Fe concentration in the yolk and white by 36.7 and 34.9%, respectively (P < 0.01).”

“Earlier studies with ruminants point to a depressant effect of dietary iron on the copper status.”

“It is concluded that high dietary levels of iron , within the range of their fluctuation in silage and forage, can impair the copper status of ruminants, especially when concurrent intakes of copper are low.”

“A significant negative correlation was observed between the concentrations of Cu and Fe (rho = -0.634, p = 0.001), Cu and Zn (rho = -0.794, p = 0.000) in whole milk.”

“The results showed that copper concentrations in soil and forage were significantly lower, and the iron content was significantly higher in affected compared with healthy area (P < 0.01).”

“However, copper can also be toxic in cells due to its redox properties and ability to disrupt active sites of metalloproteins, such as Fe –S enzymes.”

“Perturbations of iron and copper (Cu) homeostasis have been shown to contribute to the pathogenesis of NAFLD.”

“ Copper influences iron content in the brain through ferroxidase ceruloplasmin activity; therefore decreased protein-bound copper in brain may enhance iron accumulation and the associated oxidative stress.”

“The biological interaction between copper and iron is best exemplified by the decreased activity of multicopper ferroxidases under conditions of copper deficiency that limits the availability of iron for erythropoiesis.”

“C, Mn, Si, P, S, B, Cr, Ni, Pb, Mo, Al, Ti, Cu, Co, V and W are common alloying elements in industrial steels, with Cr, Ni, Mo, Cu , Ti, V and Si being acknowledged as beneficial in enhancing the corrosion resistance of iron.”