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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Copper
drug:
Indomethacin
Research Papers that Mention the Interaction
“The surface area of copper of Cu-IUDs and the pH change induced by indomethacin incorporated in their frame affected the release rate of copper (p < 0.05).”
Release of copper and indomethacin from intrauterine devices immersed in simulated uterine fluid“The endometrium spiral arteries changed in morphology after insertion of copper IUD, and indomethacin may have contrary effects on copper.”
“Pretreatment of the tissue with indomethacin blocked the excitatory action of copper and frequently reversed the response into an inhibition of the contractile activity.”
“The decreased activity of ceruloplasmin and alcohol dehydrogenase by metal deficiency increased after oral indomethacin treatment, reaching the control values when indomethacin was chelated with copper.”
In vivo effects of indomethacin on the activity of metal-containing enzymes.“1.6 micrograms of Cu indomethacine administered by the same route cause a subsequent rise in GSH of 0.83 mumol/g of liver and a drop in the mixed disulphide value of 0.80 mumol of GSH equivalents.”
“It was indicated that when the copper ion is coupled with indomethacin , the drug is more potent as a bacteriostatic.”
Inhibitory Effect of Copper Complex of Indomethacin on Bacteria Studied by Microcalorimetry“Electrochemical polarization resistance measurements indicated that indomethacin powder slightly increased the corrosion rate of copper if pH of the fluid was not under control and it did not change the corrosion rate if pH was adjusted daily to maintain some constancy.”
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