Possible Interaction: Copper and Hydrogen Peroxide

“The lag time to oxidation increased by 27% [95% confidence interval (CI) 18-35%, P < 0.001] after copper and by 29% (95% CI 12-46%, P = 0.002) after haemin plus H2O2 in the supplemented group as compared to the placebo group by t-tests.”

“Significance: The antioxidant enzyme, Cu ,Zn-SOD, increases mitochondrial H2O2 levels, which is linked to pulmonary fibrosis.”

“Zn Cu induced the electrical potential recorded on intact skin, enhanced H2O2 production and activated p38 MAPK and Hsp27 in primary keratinocytes.”

“… copper ions … hydroperoxides , and allows the production of LDL rich in hydroperoxides (626+/-98 nmol/mg LDL protein) but low in oxysterols (3+/-1 nmol 7-… microg (125)I-labelled hydroperoxide-rich LDL vs. 0.46+/-0.04 microg protein/mg cell protein in 18 h for native LDL).”

“Here, we show that a formulation of copper metal ions in combination with hydrogen peroxide dramatically reduces the level of prion protein (PrP)(Sc) (the scrapie isoform of PrP) present in homogenates of samples from prion-infected brains, including brain samples from humans with CJD.”

“ Hydrogen peroxide induced subtle changes in the tertiary structure but not the secondary structure of Cu ,E SOD as detected by near and far UV circular dichroism.”

“Contrary to previous reports, all the mutant Cu ,Zn-SODs exhibited less reactive oxidant producing ability in the presence of hydrogen peroxide than the wild-type enzyme.”

“Catalase is …: (1) H2O2 inhibits … inactivates Cu ,Zn-SOD, so the removal of H2O2 is necessary for preventing this inhibition and (2) for kinetic reasons, the assay should … with the product (H2O2) as low as possible, so that the equilibrium will not be shifted in favor of O2·- production.”

“The strong interaction between different phases layers caused multiple amplification of signal and introduction of Cu NCs further improve PEC properties and catalytic activity to hydrogen peroxide (H2O2) what can catalyze lecuo-methylene blue (lecuo-MB) from colorless to blue.”

“In the absence of chelating agents, the copper ions generated a significant level of hydroxyl radicals in a Fenton‐like reaction with hydrogen peroxide at pH = 10.”