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Last Updated: 4 months ago

Possible Interaction: Copper and Homocysteine





Research Papers that Mention the Interaction

In addition to finding that Hcy is involved in cholesterol homeostasis in neurons, we demonstrate that the combined effect of cholesterol and Hcy in the presence of copper significantly increases the levels of reactive oxygen species and may render neurons more vulnerable to Aβ.
CNS & neurological disorders drug targets  •  2013  |  View Paper
Hyperhomocysteinemia is a risk factor for neurodegeneration, and binding of copper by homocysteine is a putative underlying mechanism.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases  •  2011  |  View Paper
However, SH-SY5Y cell death was observed following exposure to micromolar level of homocysteine in combination with copper.
Neuroscience Research  •  2010  |  View Paper
The capacity of homocysteine to regenerate ascorbic acid from dehydroascorbic acid appeared to play a minor role in inhibition of ascorbic acid oxidation by copper as compared to copper chelation by homocysteine.
Biochimica et biophysica acta  •  2005  |  View Paper
We examined the effect of homocysteine-induced oxidative stress on human embryonic palatal mesenchyme (HEPM) cells and demonstrated that biologically relevant levels of homocysteine (20–100 μM) with copper (10 μM) resulted in dose-dependant apoptosis, which was prevented by addition of catalase but not superoxide dismutase.
We have demonstrated that biologically relevant levels of homocysteine in combination with copper can results in apoptosis as a result of oxidative stress; therefore, homocysteine has the potential to disrupt normal palate development.
In Vitro Cellular & Developmental Biology - Animal  •  2003  |  View Paper
Further studies are required to establish whether the concomitant increase in Hcy and copper plays an etiological role in vein graft disease.
Interactions between Hcy and copper may mediate the vasculopathic impact of Hcy, and this may play a role in vein graft failure.
The Annals of thoracic surgery  •  2002  |  View Paper
Using ECV304 cells, we found that homocysteine (Hcy) plus copper (Cu2+) induced cytotoxic effects: loss of cell adhesion, increased permeability to PI, and the occurrence of morphologically apoptotic cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  2001  |  View Paper
Furthermore, in the presence of copper ions together with 100 micromol/l of adenosine and homocysteine a significantly retarded cell growth was observed in HeLa cell cultures.
Toxicology  •  2000  |  View Paper
We have recently shown that low concentrations of copper ions increased the extracellular concentration of homocysteine in a HeLa cell culture system.
Clinical chemistry and laboratory medicine  •  2000  |  View Paper
In HeLa cell lines the release of homocysteine was found to be a continuous process, which was increased in the presence of copper ions.
Biochimica et biophysica acta  •  1998  |  View Paper
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