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“Previously physiological experiments carried out on mice have proved that copper and zinc can interfere with the pharmacological effects of histamine that lead to anaphylactic shock.”
“The inhibitory effect depended on the ability of mast cell-derived histamine , released from the exocytosed granules into the medium, to bind the copper ions necessary for propagation of the macrophage-initiated oxidation of LDL.”
The Journal of biological chemistry • 1993 | View Paper
“ Histamine is certainly the main mediator involved in CU but probably not the only one, as cell activation is followed by the release of other inflammatory substances as well.”
The Israel Medical Association journal : IMAJ • 2002 | View Paper
“In the presence of histamine , the strong red fluorescence of copper nanoparticles is obvious decreased through interaction of copper nanoparticles and histamine.”
“The significant inhibitory effect on 48/80-induced histamine release of the copper and cobalt lidocaine complexes was observed in concentration of 10(-4) M. Histamine release by ionophores A23187 and X537A was also affected by zinc lidocaine complexes.”