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“This result supports that the positive guanidinium plays a role in the catalytic mechanism of Cu ,Zn-SOD by ensuring that superoxide enters and peroxide leaves rapidly from the coordination sphere of the copper ion.”
Journal of the American Chemical Society • 2006 | View Paper
“Indeed, there appears to be a high association of mutations at CC or GG sites in the mutational spectrum in the presence of copper ions , confirming the observation that copper binds preferably at two adjacent guanines in the DNA.”