Possible Interaction: Copper and Glycerol

“Here we report that both water and glycerol permeability of human AQP3 is inhibited by copper.”

“Free fatty acid (P less than 0.05) and glycerol (P less than 0.1) concentrations were higher in Cu than in C experiments.”

“At higher concentrations of copper, glycerol transport is delayed as shown by the PF‐3 availability test in which glycerol is used as the probing agent and the erythrocytes as the source of PF‐3 activity.”

“ Glycerol in trace amounts appears to enhance exponentially the attachment of trace amounts of copper to human erythrocytes, while its own penetration of the erythrocytes is unaffected.”

“A pair of hydrogen ions or a pair of copper ions are bound to the glycerol binding site and inhibit non-competitively.”

“The work of Lefevre4 showed the inhibiting action of —SH agents; for example, p-chloromercuribenzoates, iodine and … ions on glucose and glycerol transfer, the work of Jacobs and Corson5 showed the inhibition of glycerol transfer … copper , and Wilbrandt6 showed that glucose penetration is … by lachrymators whereas glycerol remains unaffected.”

“However, supplementation of glycerol-containing media with copper resulted in increases in life span of between 17 and 72%; life spans equivalent to or beyond those obtained on glucose media.”