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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Copper
supplement:
Glutathione
Research Papers that Mention the Interaction
“Thus, GSH plays a central role in the defense reactions involved in the chronic toxicity of Fe and Cu.”
“At least part of the effects of copper on GSH are related to its ability to reduce the activity of glutamate cysteine ligase, the rate limiting enzyme in GSH synthesis.”
“Together, these results suggest that in vivo iron and copper may specifically enhance nerve cell death under conditions where GSH levels are reduced.”
“Binding of copper by reduced glutathione ( GSH ) is generally seen as a mechanism to lower, if not abolish, the otherwise high electrophilicity and redox activity of its free ions.”
“The addition of copper ions (Cu2+) could oxidize GSH into glutathione disulfide (GSSG), resulting in the distinct suppression of GSH-modulated PtNP surface chemistry and oxidase-like activity inhibition, which further results in a significant acceleration of TMB oxidation and the obvious recovery of intense blue color.”
“Depletion of glutathione in the cells or loading the cells with ascorbate greatly increased heme oxygenase-1 induction in the presence of copper.”
Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate.“A strongly decreased total amount of glutathione in the presence of copper ions was observed in hepatoma cell cultures with lower cysteine levels, whereas the other agents showed effects similar to those described for cell cultures with normal cysteine levels.”
Traces of copper ions deplete glutathione in human hepatoma cell cultures with low cysteine content.“At higher concentrations of copper (> 100 μM) decrease level of GSH was noticed.”
“ Glutathione in mononuclear cells (mmol/g of protein) also increased after the 2-mo copper loading in both groups and in both genders (P = 0.01).”
“Metallothionein (MT) and reduced glutathione GSH ) play an important role in the intracellular handling of copper by preventing the generation and favouring the removal of copper-derived free radicals.”
“In HeLa cell lines with initial low cell density and in an endothelial cell line (ECV 304), even the presence of 100 micromol/l of homocysteine and 10 micromol/l of copper ions inhibited cell growth and decreased the cellular level of glutathione.”
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