Possible Interaction: Copper and Glucose

“ Cu doping was shown to improve the electrocatalytic activity for the oxidation of glucose , which resulted from the accelerated electron transfer and greatly improved electrochemical conductivity.”

“RESULTS This study showed that gl cose co nsiderably decreased the oxidation of native LDL by cop per ions. ”

“Dietary factors that may affect the bioavailability of copper include the levels of copper, zinc, and molybdenum in the diet; iron deficiency; ascorbic acid intake; intake of carbohydrates, including fructose, glucose , and starch; and fiber and phytate intakes.”

“The initial increase in glucose production was enhanced in Cu (8.1 +/- 1.6 mumol.min-1.kg-1) compared with C experiments (3.9 +/- 1.9, P less than 0.05), and plasma glucose only increased in Cu experiments.”

“During the proliferative phase, the presence of a copper IUD induced a significant decrease in the conversion of glucose to glycogen and to lactate and also a decrease in oxygen uptake and in the utilization of endogenous substrates.”

“However, Cu exposure at the lowest conductivity sharply increased the levels of glucose in the acute exposure, while there was no significant difference in the chronic exposure.”

“In vitro incubation of bovine Cu ,Zn‐SOD (Cu,Zn‐superoxide dismutase) with glucose , ribose or fructose results in a remarkable inactivation of the enzyme.”

“Tendon collagen incubated with glucose and 100 μM copper ions showed 80% reduction in pepsin digestion within seven days, indicating extensive crosslinking, whereas collagen incubated with glucose alone for the same period showed only 7% reduction.”

“However, the epinephrine-stimulated rate of glucose release was significantly reduced after 2 h of incubation with 100 microM Cu.”

“Also, a strong positive and significant correlation was observed between Cu and increasing glucose and ALT, AST, and ACP.”