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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Copper Gluconate and Irinotecan

Research Papers that Mention the Interaction

Fourier transformed infrared (FT-IR) spectroscopy indicated a strengthening of the hydrogen bonds involving the hydroxyl groups when solutions of irinotecan and copper gluconate/TEA are mixed at a 1:1 molar ratio.
Spectroscopic analyses revealed that irinotecan interacted with copper gluconate/TEA in solution.
The addition of irinotecan to liposomes containing copper gluconate/TEA at 50 degrees C induced a shift of the absorption bands from 370 nm to 378 nm as well as a 60% quenching of the drug fluorescence at 440 nm suggesting the occurrence of irinotecan self association.
The intensity of the circular dichroism (CD) signal of copper gluconate/TEA increased in the presence of equimolar amounts of irinotecan.
International journal of pharmaceutics  •  2007  |  View Paper