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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Copper
drug:
Fluvastatin
Research Papers that Mention the Interaction
“LDL … copper ions (204 μmol · l−1 LDL-C/3.2 μmol · l−1 Cu) … conjugated dienes was monitored at 234 nm for 5 h. Treatment with fluvastatin caused a reduction of diene production by 16% and of diene … 14%, effects being significantly different from placebo (P=0.02).”
Effects of fluvastatin therapy on lipids, antioxidants, oxidation of low density lipoproteins and trace metals“ Fluvastatin therapy inhibited the susceptibility of LDL to copper ion –induced oxidation, as shown by prolongation of the lag time by 22% and by a reduction of thiobarbituric acid–reactive substances (TBARS) levels by 14%, as compared with the patient's LDL baseline oxidation.”
“ Fluvastatin but not pravastatin significantly prolonged the lag time of LDL oxidized by copper ions ex vivo without affecting plasma cholesterol levels at a dose of 3 mg/kg after four weeks of treatment.”
Fluvastatin, an HMG-CoA reductase inhibitor, protects LDL from oxidative modification in hypercholesterolemic rabbits.
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