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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Copper and Fluconazole

supplement:

Copper

Research Papers that Mention the Interaction

Of the 2359 genes that were differentially expressed under conditions of cotreatment, 50% were found to be driven uniquely by exposure to both Cu and fluconazole.
G3  •  2021  |  View Paper
We recently showed that copper supplementation potentiates the activity of the azole antifungal fluconazole against the opportunistic fungal pathogen C. albicans.
JBIC Journal of Biological Inorganic Chemistry  •  2020  |  View Paper
Strikingly, FLC contributed to an increase of the DNA damage in vitro, when complexed with iron or copper in the presence of hydrogen peroxide.
PloS one  •  2018  |  View Paper
Our additional demonstration that fluconazole enhances copper toxicity for M. canis suggests that inhibition of metallothionein expression by fluconazole is biologically relevant and may represent an important additional mode of the antifungal action of this drug.
Biochemical and biophysical research communications  •  2002  |  View Paper