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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Copper
drug:
Elesclomol
Research Papers that Mention the Interaction
“Controlled supplementation of elesclomol with copper in culture medium increased Mtb sensitivity by >65 fold.”
The evaluation of the anti‐cancer drug elesclomol that forms a redox‐active copper chelate as a potential anti‐tubercular drug“Combinational treatment of elesclomol and copper leads to copper retention within mitochondria due to ATP7A loss, leading to ROS accumulation, which in turn promotes the degradation of SLC7A11, thus further enhancing oxidative stress and consequent ferroptosis in CRC cells.”
Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A.
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