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Toxicology in vitro : an international journal published in association with BIBRA • 2017 | View Paper
“The oxidation of DA however was significantly enhanced in the presence of both copper and chloride with the rate of DA oxidation greatest at intermediate chloride concentrations (0.05-0.2M).”
Folia Phoniatrica et Logopaedica • 2005 | View Paper
“This study was undertaken to investigate the protective effects of ebselen on oxidative DNA damage induced by dopamine in the presence of copper ions.”
“In wildtype mice, Cu supplementation during development caused a significant decline in dopamine and norepinepherine in the midbrain and dopamine in the frontal cortex.”
BMC Pharmacology and Toxicology • 2016 | View Paper
“Several metabolites including L-3,4-dihydroxyphenylalanine and dopamine have been previously shown to lead to oxidative DNA breakage in the presence of copper ions.”
“ Dopamine in the presence of copper ions releases aldehydic products from glutamate, deoxyuridine or DNA capable of reacting with 2-thiobarbituric acid (TBA).”
“The present data indicate that dopamine in the presence of copper ions can lead to the formation of reactive hydroxyl radicals which can release aldehydic products from glutamate, deoxyuridine or DNA capable of reacting with TBA.”
“With doses larger than 3 mg/kg the copper content was higher when measured 30 … of the metal and was depleted to near control values after 6 h. Copper ions in doses of 3, … 10 mg/kg increased dopamine and decreased noradrenaline cntents of … in a non‐linear fashion.”
“The inhibition produced by copper was competitive with a significant decrease in affinity, the 50% effective concentration of Cu2+ was 21 to 24 microM, and the potency of dopamine agonists was also decreased.”
“Combined exposure of Mn and Cu also produced a greater elevation in the levels of dopamine (DA) and norepinephrine (NE) and a depression of 5-hydroxytryptamine (5-HT) in the brain of animals fed with a 10% casein diet compared to the animals receiving the 21% casein diet.”