Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Copper and Dopamine

supplement:

Copper

Research Papers that Mention the Interaction

Herein, we investigate the pro-oxidant DNA damage induced by the interaction of L-DOPA and dopamine (DA) with copper.
Toxicology in vitro : an international journal published in association with BIBRA  •  2017  |  View Paper
The oxidation of DA however was significantly enhanced in the presence of both copper and chloride with the rate of DA oxidation greatest at intermediate chloride concentrations (0.05-0.2M).
Journal of inorganic biochemistry  •  2014  |  View Paper
It has been shown that copper ions affect the dopamine and the GABA systems.
Folia Phoniatrica et Logopaedica  •  2005  |  View Paper
This study was undertaken to investigate the protective effects of ebselen on oxidative DNA damage induced by dopamine in the presence of copper ions.
Neuroscience Letters  •  2002  |  View Paper
In wildtype mice, Cu supplementation during development caused a significant decline in dopamine and norepinepherine in the midbrain and dopamine in the frontal cortex.
BMC Pharmacology and Toxicology  •  2016  |  View Paper
Several metabolites including L-3,4-dihydroxyphenylalanine and dopamine have been previously shown to lead to oxidative DNA breakage in the presence of copper ions.
Neuroscience Letters  •  2001  |  View Paper
Dopamine in the presence of copper ions releases aldehydic products from glutamate, deoxyuridine or DNA capable of reacting with 2-thiobarbituric acid (TBA).
The present data indicate that dopamine in the presence of copper ions can lead to the formation of reactive hydroxyl radicals which can release aldehydic products from glutamate, deoxyuridine or DNA capable of reacting with TBA.
Pharmacology & toxicology  •  1991  |  View Paper
With doses larger than 3 mg/kg the copper content was higher when measured 30 … of the metal and was depleted to near control values after 6 h. Copper ions in doses of 3, … 10 mg/kg increased dopamine and decreased noradrenaline cntents of … in a non‐linear fashion.
Acta neurologica Scandinavica  •  1988  |  View Paper
The inhibition produced by copper was competitive with a significant decrease in affinity, the 50% effective concentration of Cu2+ was 21 to 24 microM, and the potency of dopamine agonists was also decreased.
Experimental Neurology  •  1986  |  View Paper
Combined exposure of Mn and Cu also produced a greater elevation in the levels of dopamine (DA) and norepinephrine (NE) and a depression of 5-hydroxytryptamine (5-HT) in the brain of animals fed with a 10% casein diet compared to the animals receiving the 21% casein diet.
Chemico-biological interactions  •  1981  |  View Paper
Show More