Possible Interaction: Copper and Disulfiram

“Accordingly, co-treatment with DSF and Cu downregulated the expression of Cyclin D1 and Cyclin A2, whereas this combination upregulated the level of P21 and P27.”

“However, the anti-tumor activity of DSF was significantly enhanced in the presence of Cu in MDS in vitro and in vivo with minimal safety profiles.”

“Numerous studies have shown that the combination of DSF and copper (DSF/Cu) greatly enhances its antitumor efficacy.”

“The enhancement of the anticancer activity by disulfiram (DSF) chelated with copper (DSF/Cu2+) has been investigated recently, while the underlying molecular mechanisms still need to be fully elucidated.”

“ Cu improved the anti‐metastatic activity of DSF , while Cu alone had no effect.”

“Our findings suggest that DSF/Cu reverses microtubule inhibitor resistance in cancer cells by suppressing ALDH2 expression, and Cu improves the activity of DSF.”

“ Disulfiram (DSF), an anti-alcoholism drug, is known to elicit cytotoxicity in many cancer cell types in the presence of copper (Cu).”

“Of these compounds, disulfiram , an off-patent drug previously used to treat alcoholism, in the presence of a copper supplement , showed low nanomolar efficacy in BTICs including those resistant to temozolomide and the highly infiltrative quiescent stem-like population.”

“Together, these findings indicate that disulfiram , particularly when administrated in combination with copper , might represent a potential repurposing agent for treatment of adult B-ALL patients, including those clinically characterized by one or more adverse prognostic factors.”

“ Disulfiram , which exhibits marked tumor inhibition mediated by copper , was encapsulated in lipid nanocapsules modified with TAT peptide (TATp) and pH-triggered sheddable PEG to target cancer cells on the basis of tumor environmental specificity.”

“Importantly, Cu improved the anti-angiogenic activity of DSF in all these assays, while copper alone had no effect.”

“These results indicate that Cu improves the anti-angiogenic activity of DSF by targeting the EGFR/Src/VEGF signaling pathway, thus providing a rationale for the use of DSF/Cu rather than DSF alone as an angiogenesis inhibitor in clinical applications.”