Possible Interaction: Copper and Dinoprostone

“CONCLUSIONS Although va inal dinoprostone ad ministration six hours prior to cop per IU D insertion in nulliparous women leads to an easy IUD insertion, we do not routinely advise it as the reduction in IUD insertion pain scores with vaginal dinoprostone lacked clinical significance.”

“Mean pain score during copper IUD insertion was lower in dinoprostone group (3.7 ± 2.3 vs. 5.0 ± 2.8; p<0.01).”

“At 500 nm, only Cu inhibited PGE2 production significantly (P<0.01, t test) by 50%.”

“ PGE2 release increased most highly in the cultures exposed to copper (6-25 fold), cobalt (7 fold), indium (4 fold), and zinc (2 fold) compared to untreated control cultures.”

“Combining copper and zinc with inhibitors of TNF secretion, transforming growth factor beta, prostaglandin E2 , and plasma alpha-globulins, resulted in a reduction of the suppressive effects of each of these agents.”

“We have … that copper (Cu) leads to a … 4-fold amplification of prostaglandin E2 (PGE2) stimulation of LHRH release from explants of the median eminence area (MEA), that this amplification is a … of [Cu], and that complexed Cu but not ionic Cu is the active form of the metal.”

“Thus, copper facilitates PGE2 stimulation of LHRH release from the MEA, and the characteristics of this facilitation are consistent with an enhancement of PGE2 binding to its receptor.”