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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Copper
drug:
Dimercaprol
Research Papers that Mention the Interaction
“TM, EDTA, PEN, BAL and DDC adminstration increased Cu excretion via bile and urine by 254, 11, 266, 46 and 16%, respectively in Group A sheep, and by 354, 13, 196, 20 and (-) 31% in Group B sheep.”
Effect of chelating agents on the excretion of copper, zinc and iron in the bile and urine of sheep.“In his seminal paper Cumings made the modest suggestion that removal of copper from the tissues of these patients with the recently discovered metal-binding agent then known as British antilewisite ( BAL ) and now marketed as Dimercaprol, might arrest the progress of this hitherto universally fatal disease.”
Treatment of Wilson's disease: the historical background.“McCance and Widdowson,’ in 1946, and Mandelbrote and associates,” in 1948, had demonstrated that the administration of dimercaprol (BAL) could produce an increased urinary excretion of copper.”
“The metal chelating compounds dimercaprol , D-penicillamine and diethyldithiocarbamate only slightly decreased the level of copper in the liver.”
“Unfortunately, disadvantages have been found in the use of BAL for the removal of Cu from the tissues of human subjects and animals.”
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