Possible Interaction: Copper and Diethyldithiocarbamate

“ DDC crosses the liposomal lipid bilayer, reacting with the entrapped copper ; a reaction that can be observed through a colour change as the solution goes from a light blue to dark brown.”

“These results suggest that DEDTC facilitates the passage of copper across the blood–brain barrier and that the combination therapy of copper and DEDTC may be an effective treatment for the neurological disturbances suffered by patients with MD.”

“In contrast, incubation with diethyldithiocarbamate (1 mM), an inhibitor of copper-containing SODs, reduced acetylcholine- and nitroprusside-induced relaxation in vessels from both R+/A+ and RA- mice.”

“It is suggested that DDC might amplify cell damage by forming intracellular, loosely-bound complexes with copper and probably also by depleting antioxidant thiols.”

“The present study suggests a role for the influence of copper by low concentrations of DEDTC in the extracellular media, the absorption and accumulation of copper in the cell and apoptotic events, induced by the cytotoxic effects that occur when DEDTC forms a complex with the copper ions.”

“This pathway is induced by … effects that occur when DEDTC forms a … the copper ions present in the culture medium and transports them into the cell, suggesting that the DEDTC by itself … able to cause cell death and the major effect is from its copper-complex in neuroblastoma cells.”

“Copper chelators, diethyldithiocarbamate and penicillamine, also inhibited the Cu ,Zn-SOD/H(2)O(2) system-induced alpha-synuclein aggregation.”

“The peroxidative activity of human Cu ,Zn-SOD was inhibited about 60% by the copper chelator, diethyldithiocarbamate (DDC) at 10 microM while the dismutation activity was not inhibited under a similar condition.”

“We found that there are differences in the effects of temperature and DDC on the dismutation and peroxidative activities of human Cu ,Zn-SOD.”

“Copper chelator diethyldithiocarbamate trihydrate DTC ) antagonized the vasoactivity induced by copper in rat mesenteric artery.”

“Previous studies have demonstrated that N,N-diethyldithiocarbamate DEDC ) elevates copper and promotes oxidative stress within the nervous system.”

“Fe-DDC forms stable NO-Fe-DDC2 complexes by … scavenging and de-nitrosylation processes, which in combination with DDC (5 mM) provoke inhibition of Cu ,Zn-SOD resulting in specific oxidative conditions culminating in potassium ion channel opening, membrane hyperpolarisation, inhibition of calcium ion influx and subsequent muscle relaxation.”