Possible Interaction: Copper and Dexamethasone

“ Cu ,Zn‐SOD activity in erythrocytes was significantly lower in Type 2 DM patients than in healthy non‐diabetic subjects.”

“When dexamethasone was added to the cells together with a high concentration of Cu (32 microM) induced the maximum MT accumulation, Cu transport into the cells decreased by 20-40% of that into non-treated cells, which was statistically significant.”

“During the late finishing period, added Cu marginally increased (P = 0.060) DM and GE digestibility while pigs fed the by-product diet had decreased DM and GE digestibility (P = 0.001) compared to those fed the corn-soy diet.”

“These results indicate that Cu supplementation alters lipid metabolism in high producing dairy cows and that Cu supplementation at 40 mg/kg of DM for 61 d can elevate liver Cu concentrations to levels considered to be marginally toxic in dairy cattle.”

“These results indicate that Cu addition to a finishing diet containing 5 mg Cu/kg DM alters lipid metabolism.”

“At the end of the 40-d receiving phase, supplemental Cu was reduced to 5 mg/kg of DM.”

“Apparent digestibility of DM and ash and N retention were increased (P < .05) by the addition of 250 ppm of Cu , whereas the addition of 5% fat decreased (P < .05) DM and ash digestibility.”

“ Dex decreased the rate of Cu , Zn superoxide dismutase synthesis (13.5 ± 3.4 nmol Phe incorporated/mg DNA/h control vs 7.2 ± 1.6, Dex) and seemed to also decrease the rate of enzyme degradation.”

“ DM showed a detection limit of 7.7 nM towards copper ions via fluorescence emission studies.”