Possible Interaction: Copper and Cysteine

“The inactivation of herpes simplex virus (HSV) by copper was enhanced by the following reducing agents at the indicated relative level: ascorbic acid > hydrogen peroxide > cysteine.”

“An unexpected formation of micro-precipitate correlating with increasing amounts of added trace elements might be caused by an interaction of cysteine and copper , and complicated the compatibility assessment with drugs.”

“The strong affinity between Cu 2 + and Cys leads to the formation of Cu2+-Cys complexes and cause the detachment of Cu2+ from the surface of NRQDs, thus the fluorescence of NRQDs recover.”

“CONCLUSION Glutathione synthesis in hepatoma cell cultures is probably more sensitive to … low cysteine level than HeLa cell cultures, and the presence of co per ions fu rther decreases the … of cys teine pr obably by increasing the disulfide binding to cysteine residues in … proteins, which causes a further decrease of total glutathione.”

“ Cysteine or cystine (100 microM) inhibited the oxidation of native LDL by copper in a simple phosphate buffer.”

“ Cysteine , but not cystine, increased the rate of lipid hydroperoxide decomposition to thiobarbituric acid-reactive substances (TBARS) in the presence of copper.”

“The conversion of these methionine residues to cysteine , by site-directed mutagenesis, strongly suggests that they coordinate to copper during the process of metal transport.”

“ Cysteine (100 microM) inhibited the modification of LDL by copper in HBSS at both pH 7.4 and 5.5 As atherosclerotic lesions may be acidic, these observations may help to explain why LDL oxidation occurs locally at these sites.”

“Reports of a potential interaction between cysteine and copper , a routine addition to parenteral nutrition solutions, have appeared in the literature.”

“ Cysteine has also been implicated in the binding of the blue (typel) copper.”

“Conclusion: In the presence of copper, Cys was extraordinarily more cytotoxic to renal cells than Hcy.”