Possible Interaction: Copper and Curcumin

“ Curcumin reduces the hepatotoxicity induced by arsenic, cadmium, chromium, copper , lead and mercury, prevents histological injury, lipid peroxidation and glutathione (GSH) depletion, maintains the liver antioxidant enzyme status and protects against mitochondrial dysfunction.”

“ Curcumin , as an anti-oxidant, possesses the abilities to scavenge radicals and maintain the levels of anti-oxidant enzymes in the presence of copper.”

“In short, curcumin has dual roles as an anti-oxidant and a prooxidant in the presence of copper and these fascinating phenomena contribute greatly to its multiple medicinal effects.”

“It has been reported that curcumin may bind low micromolar concentrations of copper , which are much lower than the copper levels in WD.”

“The unique structure of curcumin makes it form complexes of types 1:1 and 1:2 with copper with relatively high binding affinities.”

“Treatment of DNA from plasmid pBR322 and calf thymus with curcumin plus copper ion caused strand scission and the formation of 8-hydroxy-2(')-deoxyguanosine in DNA.”

“Therefore, it could be concluded that curcumin might exert a net protective effect on copper toxicity in thalassemia intermedia patients.”

“While the serum levels of zinc and zinc/copper significantly increased, the serum levels of copper decreased after 3 months of curcumin intake.”

“Moreover, curcumin treatment alleviated the decrease in mitochondrial membrane potential and the nuclear translocation of cytochrome c induced by copper.”

“Taken together, our study demonstrates that curcumin has neuroprotective properties against copper in SH-SY5Y cells and the potential mechanisms might be related to oxidative stress and mitochondrial apoptosis.”

“Conclusions: Curcumin accelerates the transport of copper within liver cells, but does not promote copper excretion from HepG2 cells.”

“CONCLUSION Supplement of co per si gnificantly enhanced the inhibitory effect of cur cumin tr eatment on migration and viability of oral cancer cells.”

“The interaction of curcumin with copper reached half-maximum at approximately 3-12 microM copper and exhibited positive cooperativity, with Kd1 approximately 10-60 microM and Kd2 approximately 1.3 microM (for binding of the first and second curcumin molecules, respectively).”

“Co-treatment with curcumin-I (30 mg/kg B.W) has shown a beneficial effect, reinstating both SCO secretory activity and serotoninergic innervation damaged by Cu exposure.”