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Possible Interaction: Copper and Curcumin



Research Papers that Mention the Interaction

Conclusions: Curcumin accelerates the transport of copper within liver cells, but does not promote copper excretion from HepG2 cells.
Medicina  •  2018  |  View Paper
CONCLUSION Supplement of copper significantly enhanced the inhibitory effect of curcumin treatment on migration and viability of oral cancer cells.
RESULTS Concentrations of curcumin which inhibited 50% OSCC cell viability (IC50) was reduced up to 5 times in the presence of 250 µM copper.
We hypothesized that intracellular copper levels may affect the sensitivity of oral cancer cells to curcumin.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2016  |  View Paper
Curcumin plus Cu (II) enhanced intracellular copper levels and potentiated curcumin-induced suppression of the nuclear factor kappa B (NF-κB) pathway, as well as alterations of mammalian target of rapamycin-raptor (mTOR) signaling.
Anticancer research  •  2010  |  View Paper
The interaction of curcumin with copper reached half-maximum at approximately 3-12 microM copper and exhibited positive cooperativity, with Kd1 approximately 10-60 microM and Kd2 approximately 1.3 microM (for binding of the first and second curcumin molecules, respectively).
Journal of Alzheimer's disease : JAD  •  2004  |  View Paper
When bound to iron or copper , the catecholamines, amino acids, and curcumin significantly shift iron oxidation potentials and stabilize Fe(3+) over Fe(2+) and Cu(2+) over Cu(+), a factor that may prevent metal redox cycling in vivo.
Dalton transactions  •  2012  |  View Paper
Administration of curcumin significantly lowered the concentrations of lipid peroxides (36%) and enhanced the antioxidant status with modulation in the levels of zinc, copper and ferritin.
Toxicology mechanisms and methods  •  2004  |  View Paper
Curcumin reduces the hepatotoxicity induced by arsenic, cadmium, chromium, copper , lead and mercury, prevents histological injury, lipid peroxidation and glutathione (GSH) depletion, maintains the liver antioxidant enzyme status and protects against mitochondrial dysfunction.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2014  |  View Paper
Curcumin , as an anti-oxidant, possesses the abilities to scavenge radicals and maintain the levels of anti-oxidant enzymes in the presence of copper.
In short, curcumin has dual roles as an anti-oxidant and a prooxidant in the presence of copper and these fascinating phenomena contribute greatly to its multiple medicinal effects.
Current pharmaceutical design  •  2013  |  View Paper
Curcumin reduced the DNA damage induced by 390 ppm copper.
The comet and micronucleus assays prove to be suitable tools to detect DNA damage by copper in the presence of curcumin.
Journal of Applied Genetics  •  2007  |  View Paper
Our results show that 50 μM curcumin in the presence of 100–200 μM copper induced DNA damage in murine lymphocytes.
The increased DNA damage by 50 μM curcumin was observed in the presence of various concentrations of copper , as detected by the alkaline comet assay.
Journal of Applied Genetics  •  2006  |  View Paper