Possible Interaction: Copper and Cuprous

“The structure of a copper site , including the number and relative position of ligands in the primary structure and the complexity of the second-coordination sphere, results in dramatically different effects of unfolding on Cu(I) affinity that has important implications for copper homeostasis.”

“Amyloid β peptide (Aβ), the major biomarker of AD, in the presence of copper ions reduces Cu2+ to Cu+ and catalyses the formation of H2O2 that subsequently induces radicals through Fenton chemistry.”

“Although apparently in contrast with the common view that Cu(I) and not Cu(II) is the … of LDL oxidation in the copper model, the results reported here indicate that the availability of Cu(I) during the initiation … oxidation promoted by copper antagonizes both antioxidant consumption … of extensive oxidation.”

“Moreover, the initial rate of Cu(II)-induced consumption of either endogenous antioxidants in LDL or free alpha-tocopherol in suspension was increased in the presence of BC, thus indicating that the continuous removal of Cu(I) enhanced both antioxidant consumption and LDL oxidation promoted by copper.”

“COMMD1-knockdown reduced the expression of Atp7b, and abolished the relocation of Atp7b back from the periphery to the trans-Golgi network membrane when the copper concentration was reduced by treatment with a Cu(I) chelator.”