Possible Interaction: Copper and Calcium Supplement

“… calcium in the supernatant liquid decreased in the … - 1 x 10(-4) mol/L copper , especially in the group of 1 x 10(-10) mol/L copper at 3rd day (P < 0.…, 1 x 10(-10) - 1 x 10(-12) mol/L copper at 7th day (P < 0.05).”

“… calcium … copper on hip fracture risk in men (p=0.051); the association between calcium and hip fracture risk was stronger when the copper concentration in ….52, 95% CI: 0.35, 0.78) as opposed to when it was low (IRR=0.88, 95% CI: 0.81, 0.94).”

“The interaction between the tested compounds and copper or iron ions is associated with a large fluorescence decrease, showing detection limits of ca.”

“A negative correlation was found between Ca and the number of amalgam fillings, and significant negative correlations were found between Ca and three other metals (Hg, Ag, and Cu ) that indicate the possibility of substitutions of Ca by three other metals.”

“Paradoxically, Ca supplementation may accentuate the problem of reduced Zn and Cu levels by impairing the absorption of simultaneously-ingested Zn and the retention of Cu (Snedeker et al. 1982; Grekas et al. 1988).”

“The relationship between Ca and Cu appears to be of particular significance.”

“Copper absorption was enhanced by the dietary levels of riboflavine, cellulose, milk proteins, oxalates and zinc, while phosphorus, niacin, calcium and pulse protein inhibited the absorption of copper.”

“The calcium and copper were significantly elevated and correlated in DS while the iron and zinc showed little change.”

“Zn explained 25.5% and the correlation was positive, whereas Ca (10.4%) had a negative correlation with the Cu content.”

“At low concentrations of Cu , the uptake tended to be more inhibited in the presence of Ca and Mg.”