Possible Interaction: Copper and Buthionine Sulfoximine

“… l-buthionine sulfoximine (BSO), a depletor of GSH …, reduced the amounts of Cu and Mo excreted into both the bile and the bloodstream, and increased the amounts of Cu and Mo … in the livers of LEC rats in the form of an insoluble complex 4h after the TTM injection.”

“Young animals experienced a substantial and persistent reduction in Cu ,Zn-SOD activity with BSO treatment.”

“ BSO pretreatment markedly decreased cellular GSH levels in MT+/+ and MT-/- cells, by 65% and 70%, respectively, which resulted in Cu cytotoxicity accompanied by its elevated redox-cycling activity and enhanced Cu-induced membrane phospholipid peroxidation.”

“ BSO reduced SCuE after both Cu doses but had no influence on RCuE. Endogenous Cu excretion was reduced by BSO in BN rats but not in WAG/Rij rats.”

“ BSO supplied in combination with Cu modified the metal effect on APX activity after 7 days of exposure and on MDHAR activity after 14 days.”

“Depletion of glutathione by pretreatment with buthionine sulfoximine significantly increased the oxidative damage by copper.”

“Since an appearance of the copper-containing materials was inhibited by buthionine sulfoximine and the partially purified copper-containing materials contained only three amino acids: glutamic acid, glycine and cystine, the materials were supposed to be gamma-glutamyl peptides phytochelatins.”