Possible Interaction: Copper and Bismuth Subsalicylate

“Excess copper induced not only oxidative stress but also ER stress.”

“2, no NS×BSS interactions (P ≥ 0.251) were observed to affect liver mineral concentration; however, the addition of BSS decreased liver concentration of Cu (P = 0.002) while increasing Fe concentration (P = 0.016).”

“Waterborne Cu exposure evoked ER stress and SREBP-1c activation and resulted in dysregulation of hepatic lipid metabolism in liver of P. fulvidraco in a time-dependent manner.”

“ Cu exposure evoked ER stress and sterol-regulator element-binding protein-1c (SREBP-1c) activation in hepatocytes of S. hasta, resulting in dysregulation of hepatic lipid metabolism.”

“ Cu exposure evoked ER stress in liver of S. hasta in a time- and concentration-course change.”

“Final liver Cu concentration was reduced (P = 0.042) by 58% in cattle fed BSS, indicating that BSS may decrease Cu absorption and storage in the liver.”

“It is shown that the level of Cu addition significantly affects both the flow stress and the ductility of the samples.”

“Under Cu stress , the plant Cu concentration and oxidative damage were greater, photosynthetic parameters and biomass declined, and antioxidant enzyme activities and the proline concentration increased.”

“The Cu removal was decreased from ~ 35 to ~ 0% as Cu stress raised from 0 to 200 mg/L, which confirmed the low binding of Cu cations to EPS.”

“Severe protein … modifications upon Cu exposure occurred in both tissues, suggesting … when hormonal adjustments to cope with Cu stress occurred mainly at the root apex, the entire root is compromised in the protein turnover … seems to be necessary to trigger and/or to sustain defense mechanisms against Cu toxicity.”

“Results showed that Cu stress induced a compositional change in the soil microbiome, with an enrichment of metal resistant bacteria in soils with higher Cu concentrations.”