“In conclusion, apigenin could exert neuroprotection against Aβ-induced toxicity in the presence of copper mainly through the mechanisms that regulate redox imbalance, preserve mitochondrial function, inhibit MAPK pathways, and depress neuronal apoptosis.”
“Our results showed that apigenin protected neurons against Aβ-mediated toxicity induced by copper , which was characterized by increasing neuronal viability and relieving mitochondrial membrane dissipation and neuronal nuclear condensation.”