supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Copper
drug:
Aldesleukin
Research Papers that Mention the Interaction
“This analysis indicated that copper modulates signal transduction pathways associated with MAPK, NF-kappaB, death receptor, IGF-I, hypoxia, IL-10, IL-2 , IL-6, EGF, Toll-like receptor, protein ubiquitination, xenobiotic metabolism, leukocyte extravasation, complement and coagulation, and sonic hedgehog signaling.”
Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper.“These data indicate that a decline in copper status decreases IL-2 production by activated human T-cells due to reduced synthesis and/or stability of IL-2 mRNA.”
“Production of interleukin 2 by human T cells was depressed by all investigated doses of copper.”
“High Cu intake also up-regulated expression levels of some pro-inflammatory mediators such as interleukin-2 (IL-2), interleukin-1β (IL-1β), and interleukin-8 (IL-8), and down-regulated the levels of expression of transforming growth factor beta (TGF-β), an anti-inflammatory mediator.”
Copper induces hepatic inflammatory responses by activation of MAPKs and NF-κB signalling pathways in the mouse.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback