Possible Interaction: Conjugated Linoleic Acid and Leptin

“ CLA supplementation might moderately decrease circulatory leptin levels only among obese adults for shorter than 24 weeks.”

“Random-effect meta-analysis found a slight but not significant reduction in plasma leptin concentrations (WMD: -0.38 ng/ml, 95% CI: -1.08, 0.32, p=0.286); I2=53.24%, p=0.001), following CLA supplementation.”

“Subgroup analysis based … showed that the CLA … leptin when used for obese subjects (WMD: -1.47 ng/ml, 95% CI: -2.15, -0.79, p<0.001) and in … trials lasting<24 weeks of duration (WMD: -0.76 ng/ml, 95% CI: -1.40, -0.12, p=0.019).”

“CONCLUSION CL su pplementation might be able to decrease circulating lep tin le vels in studies with duration of less than 8 weeks especially among male and overweight subjects.”

“Analysis of plasma leptin concentrations adjusted for adiposity by using fat mass as a covariate showed that CLA supplementation significantly decreased circulating leptin concentrations in the absence of any changes of fat mass.”

“ Leptin may mediate the effect of CLA to decrease body fat.”

“Thus, 64 d of CLA supplementation in women produced a transient decrease in leptin levels but did not alter appetite.”

“Supplementation with CLA before calving improved the recovery of plasma leptin levels in the early PP period (from the day of calving until wk 3 PP; treatment effect).”

“In both genotypes, CLA significantly reduced serum triglycerides levels and down-regulated the mRNA expressions of CCAAT/enhancer binding protein α (C/EBPα) and leptin in white adipose tissue.”

“10t 12c CLA treatment significantly decreased leptin and angiotensinogen expression in adipose tissue (4).”

“In the presence of leptin, CLA depleted adiponectin but did not induce insulin resistance or macrophage infiltration.”

“ CLA inhibited both basal and insulin-stimulated leptin gene expression and secretion (-30 to -40%, P<0.05-0.01).”

“Furthermore, the inhibition of leptin and adiponectin production induced by CLA may contribute to insulin resistance observed in CLA-treated animals and humans.”

“These results indicate that CLA inhibits leptin and adiponectin secretion and suggest that increased anaerobic metabolism of glucose may be involved in these effects.”

“trans-10,cis-12 CLA (t10c12 CLA) reduced leptin secretion and fat accumulation.”

“On the other hand, serum adipocytokines, leptin and adiponectin, were drastically decreased by CLA feeding, and DHA supplementation did not affect those levels.”