“Activation of the latent enzyme ….~-~ A number of compounds influence collagenase synthesis in these cell~.… necrosis factor-a, polypeptide growth factors such as epidermal growth factor and platelet-derived growth factor, and phorbol esters … as transforming growth factor+ (TGF-P), glucocorticoid hormones, and vitamin A analogues (retinoids) suppress it.’””