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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Collagenases
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“The 2.4 angstrom resolution structure of the inhibited enzyme revealed that, in addition to the catalytic zinc, there is a second zinc ion and a calcium ion which play a major role in stabilizing the tertiary structure of collagenase.”
Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor.“Increasing calcium concentration enhanced the rate of enzymatic digestion when using bacterial collagenase.”
“The mechanism … of collagenase was shown to be related … chelation of metallic ions, including calcium and zinc, such inhibition being reversible on addition of higher concentrations of the necessary ions, but also … irreversible, resulting from reduction of disulphide bonds in collagenase with subsequent binding to the SH site liberated.”
“ Collagenase treatment was shown to inhibit the uptake of calcium into the preparations.”
The mechanism of action of collagenase on the inhibition of release of acetylcholine from synaptosomal preparations“Both ions are required for full activity, explaining why calcium critically affects the enzymatic activity of clostridial collagenases.”
“Results: The newly identified calcium site , aspartate switch, and conformational selectivity filter regulate substrate access to the active sites of these collagenases.”
Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T*
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