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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Thirteen patients received colistin plus ascorbic acid , whereas 15 received colistin alone.”
Preliminary Clinical Study of the Effect of Ascorbic Acid on Colistin-Associated Nephrotoxicity“ CMS induced acute tubular necrosis, increased the NAG, GGT, and MDA levels, and reduced the Vitamin E, Vitamin C , SOD, CAT, and GPx activities.”
Combined use of Vitamins E and C improve nephrotoxicity induced by colistin in rats.“These results suggest that ascorbic acid could reduce colistin sulfate-induced neurotoxicity through the resistance of oxidative stress and the prevention of apoptosis mediated via mitochondria pathway.”
“They also highlight the potential of coadministering ascorbic acid to widen the therapeutic dose of colistin.”
“ Ascorbic acid (200 mg/kg) altered colistin pharmacokinetics, as the total body clearance decreased from 3.78 ± 0.36 mL/min/kg (colistin group) to 2.46 ± 0.57 mL/min/kg (P = 0.0024).”
“Co-administration of ascorbic acid has the potential to increase the therapeutic index of colistin.”
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