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“The quenching of ROS generated by curcumin-colistin combination and the use of resveratrol , an anti-oxidant, with colistin increased the persister population, supporting the significance of ROS in decreased persistence against this combination.”
“Conclusions: Resveratrol was found to potentiate colistin activity against a wide panel of colistin-resistant strains, regardless of species and resistance mechanisms, which would deserve further investigation for potential clinical applications.”
“Overall, a relevant synergistic antimicrobial activity of resveratrol in combination with colistin was observed with all tested strains, except for the three colistin-susceptible K. pneumoniae strains, and for two mcr-1-positive E. coli strains.”