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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Colistin
supplement:
Phosphatidylethanolamine
Research Papers that Mention the Interaction
“Although the mutations in pmrB were associated with colistin resistance, PEtN addition appears not to be the sole factor leading to colistin resistance, indicating that the mechanism of colistin resistance is far more complex than previously suspected and is potentially strain specific.”
Investigation of Novel pmrB and eptA Mutations in Isogenic Acinetobacter baumannii Isolates Associated with Colistin Resistance and Increased Virulence In Vivo“When looking at individual lipid species, the most abundant PE and PG species (PE 34:1 and PG 34:1) are significantly upregulated when the susceptible and the resistant strains are cultivated with colistin.”
Colistin Treatment Affects Lipid Composition of Acinetobacter baumannii“These latter ensure the addition of phosphoethanolamine moiety to lipid A of the bacterial outer membrane leading to colistin resistance.”
“MCR-1 is a phosphoethanolamine transferase that catalyzes the addition of phosphoethanolamine to lipid A to decrease colistin affinity.”
“Strong complex formation has been shown to occur between polymyxin E and monolayers of a cephalin preparation and with monolayers of the lipid material isolated from disrupted cells of Ps.”
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