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Last Updated: 2 years ago

Possible Interaction: Colistin and Phosphatidylethanolamine

Research Papers that Mention the Interaction

Although the mutations in pmrB were associated with colistin resistance, PEtN addition appears not to be the sole factor leading to colistin resistance, indicating that the mechanism of colistin resistance is far more complex than previously suspected and is potentially strain specific.
Antimicrobial Agents and Chemotherapy  •  2019  |  View Paper
When looking at individual lipid species, the most abundant PE and PG species (PE 34:1 and PG 34:1) are significantly upregulated when the susceptible and the resistant strains are cultivated with colistin.
Antibiotics  •  2021  |  View Paper
These latter ensure the addition of phosphoethanolamine moiety to lipid A of the bacterial outer membrane leading to colistin resistance.
Journal of global antimicrobial resistance  •  2021  |  View Paper
MCR-1 is a phosphoethanolamine transferase that catalyzes the addition of phosphoethanolamine to lipid A to decrease colistin affinity.
BMC Biology  •  2016  |  View Paper
Strong complex formation has been shown to occur between polymyxin E and monolayers of a cephalin preparation and with monolayers of the lipid material isolated from disrupted cells of Ps.
Biochimica et biophysica acta  •  1955  |  View Paper