Possible Interaction: Colistin and Melatonin

“In three animal models infected by mcr-1-carrying E. coli, melatonin dramatically rescues colistin efficacy.”

“Results: Melatonin , which has been approved for treating sleep disturbances and circadian disorders, substantially potentiates the activity of three antibiotics, particularly colistin , against MCR-expressing pathogens without enhancing its toxicity.”

“This is evidence that the combination of colistin with melatonin enhances bacterial outer membrane permeability, promotes oxidative damage and inhibits the effect of efflux pumps.”

“ Melatonin altered colistin pharmacokinetics; the total body clearance in the colistin-melatonin group (1.82 ± 0.26 ml/min/kg) was lower than in the colistin group (4.28 ± 0.93 ml/min/kg).”