Possible Interaction: Colistin and Edetic Acid

“In this study, we evaluated four assays based on the inhibition of MCR-1 activity by … the inhibition zones of colistin and colistin (10 μg) plus EDTA (100 mM); (ii) reduction of colistin … EDTA (80 μg/ml); (iii) a modified rapid polymyxin … zeta potential (RZP = ZP+EDTA/ZP−EDTA).”

“We obtained encouraging results for the detection of MCR-1 in E. coli isolates recovered … mm difference in the inhibition zones between colistin disks without and with EDTA; ≥4-fold colistin … EDTA ; RZP of ≥2.5; and the absence of metabolic … presence of colistin-EDTA, in the MPNP test.”