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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Colforsin
supplement:
Magnesium Cation
Research Papers that Mention the Interaction
“… Mg2+i attenuated the stimulation of … adenylyl cyclase with forskolin , inhibition of cyclic nucleotide phosphodiesterases with isobutylmethylxanthine, and inhibition of phosphoprotein phosphatases I and IIA with calyculin A. These experiments … on these upstream steps in the signaling cascade and suggested that Mg2+i acts directly on CaV1.2 channels.”
Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac CaV1.2 channel“Kact for forskolin was reduced from 10 microM to 0.1 microM as Mg++ concentration was … 0.5 mM to 40 mM. Since previous studies have shown that the allosteric effects of Mg++ are at, or closely related to, … regulatory protein, these findings suggest that forskolin may also … site.”
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