Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Colforsin and Magnesium Cation

Research Papers that Mention the Interaction

Mg2+i attenuated the stimulation of … adenylyl cyclase with forskolin , inhibition of cyclic nucleotide phosphodiesterases with isobutylmethylxanthine, and inhibition of phosphoprotein phosphatases I and IIA with calyculin A. These experiments … on these upstream steps in the signaling cascade and suggested that Mg2+i acts directly on CaV1.2 channels.
The Journal of general physiology  •  2013  |  View Paper
Kact for forskolin was reduced from 10 microM to 0.1 microM as Mg++ concentration was … 0.5 mM to 40 mM. Since previous studies have shown that the allosteric effects of Mg++ are at, or closely related to, … regulatory protein, these findings suggest that forskolin may also … site.
Endocrinology  •  1984  |  View Paper