Possible Interaction: Colforsin and Calcium Supplement

“The reduction in calcium was attenuated by pretreatment with pertussis toxin, 8-Bromo-cAMP and forskolin , indicating this progesterone action involves activation of an inhibitory G protein and downregulation of cAMP-dependent signaling.”

“Agents that increase cAMP levels, including forskolin plus 3-isobutyl-1-methylxanthine (fsk/IBMX), triggered a rise in the intracellular calcium concentration and enhanced the response to glucose by increasing both the number of cells responding to glucose and the magnitude of calcium responses in individual cells.”

“In the presence of Ca2+ and protein kinase A, the forskolin-induced AC activity is significantly, but not completely inhibited, suggesting the involvement of both Ca2+-sensitive and Ca2+-insensitive AC isoforms in the regulation of circadian rhythmicity in these cells.”

“We found a clear inhibitory effect of forskolin on the anti‐p‐induced PI turnover and [ Ca2+Ii fluxes as well as on later parameters of cell activation.”

“We also found that calcium reduced enzyme stimulation by forskolin and the GTP analog, guanyl 5'-yl imidodiphosphate [GMP-P(NH)P] in a dose-related manner and that activation by NaF was less sensitive to inhibition by calcium.”

“Furthermore, preincubation of tissues for 15 min with forskolin , a cAMP activator, markedly blocked the Isc evoked by AngII, while intracellular Ca2+ pump inhibitor thapsigargin, L-type Ca2+ channel blocker nicadipine or the epithelial Na+ channel blocker amiloride didn't show such function.”

“In neurons treated with forskolin , intracellular calcium increased to 296 +/- 38% and this was completely prevented by inhibition of Akt.”

“In cultured keratinocytes, forskolin increased the intracellular calcium concentration and both nifedipine and verapamil blocked the increase.”

“In the second half of the normal dark period removal of calcium markedly decreased NAT activity and melatonin levels in glands incubated with forskolin for either 4 or 6 hr.”

“Both the isoprenaline‐ and forskolin‐induced increases in IKr were inhibited when calcium entry was reduced by block of ICa with nifedipine or when myocytes were pre‐incubated in BAPTA‐AM.”