supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Colchicine
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“Abstract Intermittent Schilling tests and daily 57Co-labeled vitamin B12 administration and analyses of urinary and fecal radioactivity revealed that colchicine given by mouth decreased vitamin B12 absorption in all except one normal subject, and this effect was greatest when colchicine was delivered by tube into the ileum.”
“ Colchicine appears to induce reversible vitamin B12 malabsorption by altering the function of ileal mucosa.”
Mechanism of vitamin B12 malabsorption in patients receiving colchicine.“ Colchicine is highly effective in preventing these attacks but it may also disrupt the intestinal absorption of vitamin B12.”
“Attachment of colchicine to cobalamin is expected to increase the therapeutic index of the drug by limiting the side effects caused by the current nonselective administration of tubulin-targeted chemotherapeutic drugs.”
“A number of drugs are known to affect the absorption of vitamin B12 , including neomycin, potassium chloride, p-aminosalicylic acid, and colchicine.”
“ Colchicine can induce the malabsorption of vitamin B12 and other nutrients.”
“The quantity of IF-B12 receptor and the amount of vitamin B12 absorbed increased markedly to greater than normal levels during recovery from a 3-day course of colchicine.”
Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback