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Possible Interaction: Colchicine and Progesterone

supplement:

Progesterone

Research Papers that Mention the Interaction

Exposure of theca cells to colchicine caused an increase of basal progesterone secretion into the incubation medium which simultaneously decreased the steroid content in the cells.
Acta histochemica  •  1997  |  View Paper
Colchicine had no effect on cyclic AMP generation, yet it suppressed progesterone synthesis by inhibiting the conversion of pregnenolone to progesterone.
General and comparative endocrinology  •  1991  |  View Paper
Exposure … luteal cell-containing … to colchicine (100 microM), vinblastine (1 microM), and nocadazole (30 microM) resulted in a reduction in the rate of relaxin-induced plaque formation by LLCs, unequivocal evidence of an inhibitory effect of all three of these antimicrotubule agents of the rate of basal relaxin release.
Endocrinology  •  1990  |  View Paper
Colchicine increased the secretion of progesterone (1.6-fold) and 20 alpha-OH-progesterone (1.8-fold) comparably in MEM-cells but had no influence on the secretion of either progestin by GEL-cells.
Biology of reproduction  •  1988  |  View Paper
Both colchicine and the cytochalasins increased granulosa cell production of progesterone and of 20 alpha-hydroxy-pregn-4-en-3-one (20 alpha-OH-progesterone) in a dose-dependent manner.
For example, granulosa cell progesterone production was stimulated almost 2-fold by 4 microM colchicine or 2 microM/ml cytochalasin B, but 5.5-fold by 4 microM colchicine plus 2 micrograms/ml cytochalasin B.(ABSTRACT TRUNCATED AT 250 WORDS)
Biology of reproduction  •  1988  |  View Paper
FSH-stimulated progesterone biosynthesis was reduced by colchicine and nocodazole in both cell types.
Endocrinology  •  1987  |  View Paper
The … colchicine … luteal cell cholesterol metabolism: namely a 60% decline in stored cholesterol, a 3-fold rise in the activity of the cholesterol synthesizing enzyme HMG … in other cholesterol metabolizing enzymes), and a 3-fold rise in the capacity of the cells to incorporate precursor [14C]acetate into cholesterol.
Journal of steroid biochemistry  •  1986  |  View Paper
Colchicine , cytochalasin B and the calcium channel-blocker verapamil significantly reduced progesterone production by both small and large luteal cell fractions, while isoprenaline stimulated an increase in progesterone production by large luteal cell fractions only.
Journal of reproduction and fertility  •  1985  |  View Paper