Possible Interaction: Colchicine and Methionine

“ Colchicine was a potent inhibitor of release and produced 88% inhibition at a 10−3 M concentration.”

“ Colchicine at 10−3 M concentrations leads to an enlargement of condensing vacuoles in the Golgi complex.”

“ Colchicine only at 10−2 M concentrations inhibits protein synthesis, while vinblastine inhibits at 10−6 and 10−5 M by 20% and at 10−4 M by 55%.”

“Using radioimmunoassay procedures, it is shown that colchicine induces a significant increase in methionine- and leucine-enkephalin-immunoreactive material in this area of the brain.”

“Other peptides (VIP, cholecystokinin, and methionine enkephalin were only detected in significant numbers of cells following intraganglionic injections of colchicine.”

“ Colchicine inhibits amino acid transport (alpha-aminoisobutyric acid, L-methionine , and L-leucine) in hepatomas by 59-98% whereas transport in host and regenerating liver is not impeded but increased.”

“ Colchicine (4 microgram) injected into the ganglion 10 min before methionine preferentially blocked the tubulin transport, with little if any blockade of the triplet and actin.”

“Concentrations of colchicine and vinblastine above 10 −7 M completely inhibited its production.”

“Stimulation of bone resorption in organ culture by parathyroid hormone or vitamin D metabolites was blocked when colchicine was added to the medium at concentrations of 10-5- 10-7 M.”

“Moreover, for combined treatments with colchicine and pressure, the 50 per cent blocking pressure level dropped from 2200 psi at 25 ° to 2000 psi at 20 °C, using 4 × 10−5 M colchicine as the immersion medium and to 700 psi at 15 °, using 1 × 10−5 M colchicine.”

“ M ) and conversely inhibited by colchicine (over 1 ?”