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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Colchicine
supplement:
Melatonin
Research Papers that Mention the Interaction
“However, when melatonin at 10−4 M was preincubated with HeLa cells prior to addition of 10−7 M colchicine , a reduction in the mitotic index, in comparison to colchicine alone, was observed.”
Melatonin antagonizes colchicine-induced mitotic arrest“In fact, the effect can be seen with no darkening agent at all: colchicine alone produces a gradual, irreversible, dosage-dependent darkening over several hours (FIGURE 4A), which can be inhibited by melatonin (FIGURE 4B).”
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