Possible Interaction: Colchicine and Leucine

“ Colchicine also suppressed incorporation of [3H]leucine into protein, in resting as well as mitogen-stimulated lymphocytes.”

“ Colchicine inhibits amino acid transport (alpha-aminoisobutyric acid, L-methionine, and L-leucine ) in hepatomas by 59-98% whereas transport in host and regenerating liver is not impeded but increased.”

“Vinblastin to which L-53 cells are cross-resistant increases labeled colchicine uptake by L and L-53 cells 3- and 8-fold, respectively.”

“enhance colchicine uptake by L and L-53 cells 2--4-fold.”

“Administration of colchicine prior to the injection of [3H]leucine resulted in the appearance of gel bands and radioactivity in the apo-C-II and apo-C-III areas of Golgi apo-VLDL, suggesting that these can be acquired if secretion of VLDL is slowed or inhibited.”

“Two days after [3H]leucine labelling of the dorsal motor nucleus of the vagus nerve, ligation or local application of 60 mM colchicine immediately blocked the further progression of slowly migrating proteins distal to the site of treatment.”

“Whilst colchicine was able to inhibit the incorporation of [C-14] thymidine, uridine and leucine into HeLa cells, 2-hydroxy chalcone inhibited the incorporation of the two nucleotides, but not the amino acid.”